| Southborough to Superior (Colorado) | 4,709.12 mi (7,578.60 km) |
| Southborough to Superior (Wisconsin) | 3,916.82 mi (6,303.50 km) |
| Southborough to Surprise (Arizona) | 5,297.93 mi (8,526.20 km) |
| Southborough to Susanville (California) | 5,177.18 mi (8,331.86 km) |
| Southborough to Sussex (Wisconsin) | 3,938.40 mi (6,338.24 km) |
| Southborough to Suwanee (Georgia) | 4,202.82 mi (6,763.79 km) |
| Southborough to Swansea (Illinois) | 4,221.67 mi (6,794.13 km) |
| Southborough to Sweetwater (Florida) | 4,456.25 mi (7,171.63 km) |
| Southborough to Sweetwater (Texas) | 4,928.32 mi (7,931.37 km) |
| Southborough to Sycamore (Illinois) | 4,008.42 mi (6,450.92 km) |
| Southborough to Sylacauga (Alabama) | 4,334.80 mi (6,976.18 km) |
| Southborough to Sylvania (Ohio) | 3,829.93 mi (6,163.68 km) |
| Southborough to Syosset (New York) | 3,459.82 mi (5,568.04 km) |
| Southborough to Syracuse (New York) | 3,472.53 mi (5,588.50 km) |
| Southborough to Syracuse (Utah) | 4,877.62 mi (7,849.77 km) |
