| Southborough to Storm Lake (Iowa) | 4,219.51 mi (6,790.65 km) |
| Southborough to Storrs (Connecticut) | 3,366.51 mi (5,417.88 km) |
| Southborough to Stoughton (Wisconsin) | 3,985.74 mi (6,414.42 km) |
| Southborough to Stow (Ohio) | 3,764.35 mi (6,058.13 km) |
| Southborough to Streamwood (Illinois) | 3,988.08 mi (6,418.19 km) |
| Southborough to Streator (Illinois) | 4,054.75 mi (6,525.48 km) |
| Southborough to Streetsboro (Ohio) | 3,758.01 mi (6,047.93 km) |
| Southborough to Strongsville (Ohio) | 3,773.96 mi (6,073.61 km) |
| Southborough to Stuart (Florida) | 4,379.64 mi (7,048.34 km) |
| Southborough to Stuarts Draft (Virginia) | 3,810.32 mi (6,132.11 km) |
| Southborough to Sturgis (Michigan) | 3,892.35 mi (6,264.13 km) |
| Southborough to Suamico (Wisconsin) | 3,864.29 mi (6,218.97 km) |
| Southborough to Sudley (Virginia) | 3,712.54 mi (5,974.76 km) |
| Southborough to Suffern (New York) | 3,473.30 mi (5,589.73 km) |
| Southborough to Suffolk (Virginia) | 3,772.06 mi (6,070.55 km) |
