| Southborough to St. Simons (Georgia) | 4,231.28 mi (6,809.58 km) |
| Southborough to Stafford (Texas) | 4,888.44 mi (7,867.18 km) |
| Southborough to Stallings (North Carolina) | 4,012.21 mi (6,457.04 km) |
| Southborough to Stamford (Connecticut) | 3,449.83 mi (5,551.96 km) |
| Southborough to Stanford (California) | 5,396.01 mi (8,684.04 km) |
| Southborough to Stanton (California) | 5,475.50 mi (8,811.96 km) |
| Southborough to Star (Idaho) | 4,870.12 mi (7,837.69 km) |
| Southborough to Starkville (Mississippi) | 4,424.83 mi (7,121.07 km) |
| Southborough to State College (Pennsylvania) | 3,638.24 mi (5,855.19 km) |
| Southborough to Staten Island (New York) | 3,496.37 mi (5,626.86 km) |
| Southborough to Statesboro (Georgia) | 4,186.25 mi (6,737.12 km) |
| Southborough to Statesville (North Carolina) | 3,989.09 mi (6,419.82 km) |
| Southborough to Staunton (Virginia) | 3,804.96 mi (6,123.49 km) |
| Southborough to Steamboat Springs (Colorado) | 4,737.42 mi (7,624.15 km) |
| Southborough to Steiner Ranch (Texas) | 4,941.75 mi (7,952.98 km) |
