| Southborough to Southern Pines (North Carolina) | 3,956.35 mi (6,367.14 km) |
| Southborough to Southfield (Michigan) | 3,778.05 mi (6,080.18 km) |
| Southborough to Southgate (Michigan) | 3,788.05 mi (6,096.28 km) |
| Southborough to Southlake (Texas) | 4,778.40 mi (7,690.10 km) |
| Southborough to Spanaway (Washington) | 4,845.11 mi (7,797.45 km) |
| Southborough to Spanish Fork (Utah) | 4,916.94 mi (7,913.05 km) |
| Southborough to Spanish Lake (Missouri) | 4,218.79 mi (6,789.49 km) |
| Southborough to Spanish Springs (Nevada) | 5,192.95 mi (8,357.25 km) |
| Southborough to Sparks (Nevada) | 5,199.11 mi (8,367.15 km) |
| Southborough to Spartanburg (South Carolina) | 4,072.10 mi (6,553.41 km) |
| Southborough to Spearfish (South Dakota) | 4,427.99 mi (7,126.15 km) |
| Southborough to Speedway (Indiana) | 4,017.20 mi (6,465.06 km) |
| Southborough to Spencer (Iowa) | 4,193.63 mi (6,749.00 km) |
| Southborough to Spokane (Washington) | 4,677.50 mi (7,527.71 km) |
| Southborough to Spokane Valley (Washington) | 4,672.20 mi (7,519.18 km) |
