| Southborough to Shelton (Connecticut) | 3,424.02 mi (5,510.42 km) |
| Southborough to Shelton (Washington) | 4,856.27 mi (7,815.42 km) |
| Southborough to Shenandoah (Louisiana) | 4,665.83 mi (7,508.93 km) |
| Southborough to Shepherdsville (Kentucky) | 4,080.77 mi (6,567.37 km) |
| Southborough to Sheridan (Wyoming) | 4,515.65 mi (7,267.24 km) |
| Southborough to Sherman (Texas) | 4,723.43 mi (7,601.63 km) |
| Southborough to Sherrelwood (Colorado) | 4,708.66 mi (7,577.86 km) |
| Southborough to Sherwood (Arkansas) | 4,489.70 mi (7,225.48 km) |
| Southborough to Sherwood (Oregon) | 4,956.02 mi (7,975.94 km) |
| Southborough to Shiloh (Illinois) | 4,218.85 mi (6,789.58 km) |
| Southborough to Shiloh (Ohio) | 3,936.88 mi (6,335.80 km) |
| Southborough to Shiloh (Pennsylvania) | 3,631.03 mi (5,843.57 km) |
| Southborough to Shirley (New York) | 3,434.98 mi (5,528.06 km) |
| Southborough to Shively (Kentucky) | 4,075.07 mi (6,558.18 km) |
| Southborough to Shoreline (Washington) | 4,805.37 mi (7,733.49 km) |
