| Southborough to Scottsboro (Alabama) | 4,254.68 mi (6,847.25 km) |
| Southborough to Scottsdale (Arizona) | 5,277.52 mi (8,493.35 km) |
| Southborough to Scranton (Pennsylvania) | 3,522.86 mi (5,669.50 km) |
| Southborough to Seabrook (Maryland) | 3,677.47 mi (5,918.31 km) |
| Southborough to Seabrook (Texas) | 4,869.59 mi (7,836.85 km) |
| Southborough to Seaford (New York) | 3,465.75 mi (5,577.58 km) |
| Southborough to Seagoville (Texas) | 4,770.55 mi (7,677.45 km) |
| Southborough to Seal Beach (California) | 5,480.65 mi (8,820.25 km) |
| Southborough to Searcy (Arkansas) | 4,451.88 mi (7,164.61 km) |
| Southborough to Seaside (California) | 5,432.26 mi (8,742.38 km) |
| Southborough to SeaTac (Washington) | 4,822.02 mi (7,760.30 km) |
| Southborough to Seattle (Washington) | 4,812.61 mi (7,745.15 km) |
| Southborough to Sebastian (Florida) | 4,360.52 mi (7,017.57 km) |
| Southborough to Sebring (Florida) | 4,416.89 mi (7,108.30 km) |
| Southborough to Secaucus (New Jersey) | 3,484.44 mi (5,607.66 km) |
