| Southborough to Santa Rosa (California) | 5,352.52 mi (8,614.06 km) |
| Southborough to Santaquin (Utah) | 4,929.53 mi (7,933.31 km) |
| Southborough to Santee (California) | 5,496.51 mi (8,845.78 km) |
| Southborough to Sapulpa (Oklahoma) | 4,582.05 mi (7,374.10 km) |
| Southborough to Saraland (Alabama) | 4,525.38 mi (7,282.90 km) |
| Southborough to Sarasota (Florida) | 4,469.93 mi (7,193.65 km) |
| Southborough to Sarasota Springs (Florida) | 4,468.53 mi (7,191.41 km) |
| Southborough to Saratoga (California) | 5,400.92 mi (8,691.94 km) |
| Southborough to Saratoga Springs (New York) | 3,376.24 mi (5,433.53 km) |
| Southborough to Saratoga Springs (Utah) | 4,913.04 mi (7,906.78 km) |
| Southborough to Sartell (Minnesota) | 4,042.54 mi (6,505.84 km) |
| Southborough to Satellite Beach (Florida) | 4,345.93 mi (6,994.09 km) |
| Southborough to Sauk Rapids (Minnesota) | 4,041.15 mi (6,503.60 km) |
| Southborough to Sault Ste. Marie (Michigan) | 3,645.24 mi (5,866.44 km) |
| Southborough to Savage (Minnesota) | 4,052.55 mi (6,521.96 km) |
