| Southborough to Salisbury (New York) | 3,465.22 mi (5,576.74 km) |
| Southborough to Salisbury (North Carolina) | 3,979.00 mi (6,403.58 km) |
| Southborough to Salmon Creek (Washington) | 4,931.05 mi (7,935.76 km) |
| Southborough to Salt Lake City (Utah) | 4,889.97 mi (7,869.64 km) |
| Southborough to Sammamish (Washington) | 4,806.28 mi (7,734.96 km) |
| Southborough to San Angelo (Texas) | 4,983.86 mi (8,020.75 km) |
| Southborough to San Anselmo (California) | 5,375.51 mi (8,651.04 km) |
| Southborough to San Antonio (Texas) | 5,013.53 mi (8,068.49 km) |
| Southborough to San Benito (Texas) | 5,154.37 mi (8,295.16 km) |
| Southborough to San Bernardino (California) | 5,433.41 mi (8,744.23 km) |
| Southborough to San Bruno (California) | 5,392.17 mi (8,677.86 km) |
| Southborough to San Buenaventura (California) | 5,487.96 mi (8,832.01 km) |
| Southborough to San Carlos (California) | 5,394.74 mi (8,681.99 km) |
| Southborough to San Carlos Park (Florida) | 4,482.56 mi (7,213.98 km) |
| Southborough to San Clemente (California) | 5,483.08 mi (8,824.17 km) |
