| Southborough to Odessa (Texas) | 5,032.48 mi (8,099.00 km) |
| Southborough to Ogden (Utah) | 4,866.64 mi (7,832.09 km) |
| Southborough to Oildale (California) | 5,415.32 mi (8,715.11 km) |
| Southborough to Ojus (Florida) | 4,438.12 mi (7,142.46 km) |
| Southborough to Okemos (Michigan) | 3,812.50 mi (6,135.62 km) |
| Southborough to Oklahoma City (Oklahoma) | 4,663.23 mi (7,504.74 km) |
| Southborough to Okmulgee (Oklahoma) | 4,598.53 mi (7,400.62 km) |
| Southborough to Olathe (Kansas) | 4,389.76 mi (7,064.63 km) |
| Southborough to Old Jamestown (Missouri) | 4,219.31 mi (6,790.32 km) |
| Southborough to Oldsmar (Florida) | 4,439.65 mi (7,144.92 km) |
| Southborough to Olean (New York) | 3,605.01 mi (5,801.70 km) |
| Southborough to Olive Branch (Mississippi) | 4,391.32 mi (7,067.14 km) |
| Southborough to Olivehurst (California) | 5,282.09 mi (8,500.71 km) |
| Southborough to Olney (Maryland) | 3,679.11 mi (5,920.95 km) |
| Southborough to Olympia (Washington) | 4,860.77 mi (7,822.65 km) |
