| Southborough to Enumclaw (Washington) | 4,827.70 mi (7,769.44 km) |
| Southborough to Ephrata (Pennsylvania) | 3,596.98 mi (5,788.77 km) |
| Southborough to Erie (Colorado) | 4,699.44 mi (7,563.02 km) |
| Southborough to Erie (Pennsylvania) | 3,668.77 mi (5,904.32 km) |
| Southborough to Erlanger (Kentucky) | 3,988.24 mi (6,418.45 km) |
| Southborough to Escanaba (Michigan) | 3,778.23 mi (6,080.48 km) |
| Southborough to Escondido (California) | 5,483.47 mi (8,824.80 km) |
| Southborough to Española (New Mexico) | 4,948.99 mi (7,964.63 km) |
| Southborough to Essex (Maryland) | 3,646.53 mi (5,868.52 km) |
| Southborough to Essex Junction (Vermont) | 3,291.47 mi (5,297.12 km) |
| Southborough to Estelle (Louisiana) | 4,657.59 mi (7,495.66 km) |
| Southborough to Estero (Florida) | 4,483.99 mi (7,216.28 km) |
| Southborough to Euclid (Ohio) | 3,749.23 mi (6,033.80 km) |
| Southborough to Eufaula (Alabama) | 4,351.65 mi (7,003.30 km) |
| Southborough to Eugene (Oregon) | 5,038.60 mi (8,108.85 km) |
