| Southborough to Emeryville (California) | 5,375.73 mi (8,651.40 km) |
| Southborough to Emmaus (Pennsylvania) | 3,553.63 mi (5,719.01 km) |
| Southborough to Emporia (Kansas) | 4,465.08 mi (7,185.85 km) |
| Southborough to Encinitas (California) | 5,494.53 mi (8,842.60 km) |
| Southborough to Endicott (New York) | 3,509.29 mi (5,647.66 km) |
| Southborough to Endwell (New York) | 3,506.73 mi (5,643.54 km) |
| Southborough to Englewood (Colorado) | 4,718.49 mi (7,593.67 km) |
| Southborough to Englewood (Florida) | 4,480.27 mi (7,210.30 km) |
| Southborough to Englewood (New Jersey) | 3,475.90 mi (5,593.93 km) |
| Southborough to Englewood (Ohio) | 3,937.63 mi (6,337.00 km) |
| Southborough to Enid (Oklahoma) | 4,628.72 mi (7,449.20 km) |
| Southborough to Ennis (Texas) | 4,790.89 mi (7,710.19 km) |
| Southborough to Ensley (Florida) | 4,507.61 mi (7,254.30 km) |
| Southborough to Enterprise (Alabama) | 4,409.05 mi (7,095.69 km) |
| Southborough to Enterprise (Nevada) | 5,260.66 mi (8,466.22 km) |
