| Southborough to Eau Claire (Wisconsin) | 3,981.94 mi (6,408.31 km) |
| Southborough to Echelon (New Jersey) | 3,563.01 mi (5,734.11 km) |
| Southborough to Eden (North Carolina) | 3,909.07 mi (6,291.04 km) |
| Southborough to Eden Prairie (Minnesota) | 4,051.58 mi (6,520.39 km) |
| Southborough to Edgewater (Florida) | 4,321.55 mi (6,954.86 km) |
| Southborough to Edgewater (New Jersey) | 3,478.84 mi (5,598.65 km) |
| Southborough to Edgewood (Maryland) | 3,635.26 mi (5,850.38 km) |
| Southborough to Edgewood (Washington) | 4,833.81 mi (7,779.26 km) |
| Southborough to Edina (Minnesota) | 4,046.01 mi (6,511.43 km) |
| Southborough to Edinburg (Texas) | 5,164.91 mi (8,312.12 km) |
| Southborough to Edmond (Oklahoma) | 4,649.25 mi (7,482.25 km) |
| Southborough to Edmonds (Washington) | 4,802.51 mi (7,728.89 km) |
| Southborough to Edwards (Colorado) | 4,775.72 mi (7,685.78 km) |
| Southborough to Edwardsville (Illinois) | 4,210.10 mi (6,775.51 km) |
| Southborough to Effingham (Illinois) | 4,138.73 mi (6,660.64 km) |
