| Southaven to Southern Pines (North Carolina) | 597.93 mi (962.27 km) |
| Southaven to Southfield (Michigan) | 633.17 mi (1,018.98 km) |
| Southaven to Southgate (Michigan) | 620.01 mi (997.81 km) |
| Southaven to Southlake (Texas) | 433.44 mi (697.56 km) |
| Southaven to Spanaway (Washington) | 1,869.76 mi (3,009.09 km) |
| Southaven to Spanish Fork (Utah) | 1,235.68 mi (1,988.63 km) |
| Southaven to Spanish Lake (Missouri) | 265.41 mi (427.14 km) |
| Southaven to Spanish Springs (Nevada) | 1,655.92 mi (2,664.95 km) |
| Southaven to Sparks (Nevada) | 1,658.23 mi (2,668.66 km) |
| Southaven to Spartanburg (South Carolina) | 455.98 mi (733.83 km) |
| Southaven to Spearfish (South Dakota) | 985.01 mi (1,585.23 km) |
| Southaven to Speedway (Indiana) | 392.20 mi (631.19 km) |
| Southaven to Spencer (Iowa) | 630.34 mi (1,014.43 km) |
| Southaven to Spokane (Washington) | 1,660.53 mi (2,672.37 km) |
| Southaven to Spokane Valley (Washington) | 1,651.86 mi (2,658.41 km) |
