| Southaven to Scottsbluff (Nebraska) | 879.92 mi (1,416.10 km) |
| Southaven to Scottsboro (Alabama) | 223.95 mi (360.41 km) |
| Southaven to Scottsdale (Arizona) | 1,249.51 mi (2,010.89 km) |
| Southaven to Scranton (Pennsylvania) | 894.52 mi (1,439.59 km) |
| Southaven to Seabrook (Maryland) | 775.46 mi (1,247.98 km) |
| Southaven to Seabrook (Texas) | 474.04 mi (762.89 km) |
| Southaven to Seaford (New York) | 980.77 mi (1,578.40 km) |
| Southaven to Seagoville (Texas) | 409.00 mi (658.23 km) |
| Southaven to Seal Beach (California) | 1,599.35 mi (2,573.90 km) |
| Southaven to Searcy (Arkansas) | 101.30 mi (163.03 km) |
| Southaven to Seaside (California) | 1,780.23 mi (2,865.01 km) |
| Southaven to SeaTac (Washington) | 1,870.42 mi (3,010.15 km) |
| Southaven to Seattle (Washington) | 1,874.90 mi (3,017.37 km) |
| Southaven to Sebastian (Florida) | 747.13 mi (1,202.38 km) |
| Southaven to Sebring (Florida) | 720.85 mi (1,160.09 km) |
