| Southaven to Oskaloosa (Iowa) | 461.31 mi (742.41 km) |
| Southaven to Oswego (Illinois) | 473.54 mi (762.09 km) |
| Southaven to Oswego (New York) | 928.37 mi (1,494.07 km) |
| Southaven to Otsego (Minnesota) | 737.98 mi (1,187.66 km) |
| Southaven to Ottawa (Illinois) | 446.88 mi (719.18 km) |
| Southaven to Ottawa (Kansas) | 385.99 mi (621.19 km) |
| Southaven to Ottumwa (Iowa) | 439.76 mi (707.73 km) |
| Southaven to Overland (Missouri) | 259.67 mi (417.89 km) |
| Southaven to Overland Park (Kansas) | 376.17 mi (605.38 km) |
| Southaven to Overlea (Maryland) | 800.46 mi (1,288.22 km) |
| Southaven to Oviedo (Florida) | 674.42 mi (1,085.37 km) |
| Southaven to Owasso (Oklahoma) | 341.37 mi (549.38 km) |
| Southaven to Owatonna (Minnesota) | 654.71 mi (1,053.65 km) |
| Southaven to Owensboro (Kentucky) | 250.85 mi (403.71 km) |
| Southaven to Owings Mills (Maryland) | 787.64 mi (1,267.58 km) |
