| Southampton to Shoreham-by-Sea | 49.55 mi (79.75 km) |
| Southampton to Shotley Bridge | 274.78 mi (442.22 km) |
| Southampton to Shrewsbury | 137.43 mi (221.17 km) |
| Southampton to Sidcup | 74.64 mi (120.12 km) |
| Southampton to Sidmouth | 81.60 mi (131.32 km) |
| Southampton to Sileby | 126.98 mi (204.35 km) |
| Southampton to Sittingbourne | 97.78 mi (157.35 km) |
| Southampton to Skegness | 171.72 mi (276.36 km) |
| Southampton to Skelmersdale | 191.91 mi (308.85 km) |
| Southampton to Skipton | 212.99 mi (342.77 km) |
| Southampton to Sleaford | 150.68 mi (242.49 km) |
| Southampton to Slough | 54.78 mi (88.16 km) |
| Southampton to Small Heath | 109.52 mi (176.26 km) |
| Southampton to Smethwick | 112.53 mi (181.09 km) |
| Southampton to Snaresbrook | 77.47 mi (124.68 km) |
