| South River to Southern Pines (North Carolina) | 454.75 mi (731.84 km) |
| South River to Southfield (Michigan) | 480.57 mi (773.41 km) |
| South River to Southgate (Michigan) | 473.63 mi (762.24 km) |
| South River to Southlake (Texas) | 1,358.56 mi (2,186.39 km) |
| South River to Spanaway (Washington) | 2,401.65 mi (3,865.07 km) |
| South River to Spanish Fork (Utah) | 1,949.52 mi (3,137.45 km) |
| South River to Spanish Lake (Missouri) | 849.08 mi (1,366.46 km) |
| South River to Spanish Springs (Nevada) | 2,369.26 mi (3,812.95 km) |
| South River to Sparks (Nevada) | 2,373.26 mi (3,819.39 km) |
| South River to Spartanburg (South Carolina) | 560.59 mi (902.18 km) |
| South River to Spearfish (South Dakota) | 1,517.56 mi (2,442.28 km) |
| South River to Speedway (Indiana) | 628.29 mi (1,011.13 km) |
| South River to Spencer (Iowa) | 1,083.38 mi (1,743.52 km) |
| South River to Spokane (Washington) | 2,165.72 mi (3,485.39 km) |
| South River to Spokane Valley (Washington) | 2,156.51 mi (3,470.57 km) |
