| South Lyon to Superior (Colorado) | 1,128.50 mi (1,816.15 km) |
| South Lyon to Superior (Wisconsin) | 507.13 mi (816.15 km) |
| South Lyon to Surprise (Arizona) | 1,669.80 mi (2,687.29 km) |
| South Lyon to Susanville (California) | 1,904.41 mi (3,064.85 km) |
| South Lyon to Sussex (Wisconsin) | 236.28 mi (380.25 km) |
| South Lyon to Suwanee (Georgia) | 581.55 mi (935.92 km) |
| South Lyon to Swansea (Illinois) | 428.39 mi (689.43 km) |
| South Lyon to Sweetwater (Florida) | 1,167.56 mi (1,879.00 km) |
| South Lyon to Sweetwater (Texas) | 1,145.84 mi (1,844.05 km) |
| South Lyon to Sycamore (Illinois) | 259.28 mi (417.27 km) |
| South Lyon to Sylacauga (Alabama) | 656.93 mi (1,057.22 km) |
| South Lyon to Sylvania (Ohio) | 52.00 mi (83.68 km) |
| South Lyon to Syosset (New York) | 535.98 mi (862.58 km) |
| South Lyon to Syracuse (New York) | 382.94 mi (616.28 km) |
| South Lyon to Syracuse (Utah) | 1,460.53 mi (2,350.50 km) |
