| South Lyon to Storm Lake (Iowa) | 587.22 mi (945.04 km) |
| South Lyon to Storrs (Connecticut) | 585.46 mi (942.21 km) |
| South Lyon to Stoughton (Wisconsin) | 284.60 mi (458.03 km) |
| South Lyon to Stow (Ohio) | 144.66 mi (232.80 km) |
| South Lyon to Streamwood (Illinois) | 233.44 mi (375.68 km) |
| South Lyon to Streator (Illinois) | 282.17 mi (454.12 km) |
| South Lyon to Streetsboro (Ohio) | 145.68 mi (234.44 km) |
| South Lyon to Strongsville (Ohio) | 122.77 mi (197.58 km) |
| South Lyon to Stuart (Florida) | 1,072.05 mi (1,725.31 km) |
| South Lyon to Stuarts Draft (Virginia) | 391.68 mi (630.35 km) |
| South Lyon to Sturgis (Michigan) | 101.39 mi (163.17 km) |
| South Lyon to Suamico (Wisconsin) | 267.26 mi (430.11 km) |
| South Lyon to Sudley (Virginia) | 410.49 mi (660.62 km) |
| South Lyon to Suffern (New York) | 498.44 mi (802.16 km) |
| South Lyon to Suffolk (Virginia) | 545.68 mi (878.18 km) |
