| South Lyon to Southern Pines (North Carolina) | 551.64 mi (887.78 km) |
| South Lyon to Southfield (Michigan) | 20.01 mi (32.20 km) |
| South Lyon to Southgate (Michigan) | 28.91 mi (46.52 km) |
| South Lyon to Southlake (Texas) | 985.60 mi (1,586.17 km) |
| South Lyon to Spanaway (Washington) | 1,908.12 mi (3,070.82 km) |
| South Lyon to Spanish Fork (Utah) | 1,455.48 mi (2,342.37 km) |
| South Lyon to Spanish Lake (Missouri) | 427.07 mi (687.30 km) |
| South Lyon to Spanish Springs (Nevada) | 1,872.26 mi (3,013.11 km) |
| South Lyon to Sparks (Nevada) | 1,876.39 mi (3,019.75 km) |
| South Lyon to Spartanburg (South Carolina) | 527.64 mi (849.15 km) |
| South Lyon to Spearfish (South Dakota) | 1,017.96 mi (1,638.25 km) |
| South Lyon to Speedway (Indiana) | 228.49 mi (367.72 km) |
| South Lyon to Spencer (Iowa) | 584.46 mi (940.60 km) |
| South Lyon to Spokane (Washington) | 1,673.22 mi (2,692.78 km) |
| South Lyon to Spokane Valley (Washington) | 1,663.98 mi (2,677.92 km) |
