| South Lyon to Smithville (Missouri) | 607.78 mi (978.13 km) |
| South Lyon to Smyrna (Delaware) | 473.55 mi (762.11 km) |
| South Lyon to Smyrna (Georgia) | 595.91 mi (959.03 km) |
| South Lyon to Smyrna (Tennessee) | 474.17 mi (763.10 km) |
| South Lyon to Snellville (Georgia) | 594.87 mi (957.34 km) |
| South Lyon to Snoqualmie (Washington) | 1,878.77 mi (3,023.59 km) |
| South Lyon to Snyder (Texas) | 1,156.74 mi (1,861.60 km) |
| South Lyon to Socastee (South Carolina) | 656.48 mi (1,056.51 km) |
| South Lyon to Socorro (Texas) | 1,446.88 mi (2,328.53 km) |
| South Lyon to Soddy-Daisy (Tennessee) | 504.43 mi (811.80 km) |
| South Lyon to Solana Beach (California) | 1,934.42 mi (3,113.14 km) |
| South Lyon to Soledad (California) | 2,035.88 mi (3,276.44 km) |
| South Lyon to Solon (Ohio) | 135.84 mi (218.61 km) |
| South Lyon to Somers Point (New Jersey) | 519.70 mi (836.37 km) |
| South Lyon to Somerset (Kentucky) | 375.04 mi (603.58 km) |
