| South Lyon to Scottsbluff (Nebraska) | 1,023.17 mi (1,646.63 km) |
| South Lyon to Scottsboro (Alabama) | 555.38 mi (893.80 km) |
| South Lyon to Scottsdale (Arizona) | 1,640.37 mi (2,639.92 km) |
| South Lyon to Scranton (Pennsylvania) | 416.85 mi (670.86 km) |
| South Lyon to Seabrook (Maryland) | 429.59 mi (691.37 km) |
| South Lyon to Seabrook (Texas) | 1,091.64 mi (1,756.82 km) |
| South Lyon to Seaford (New York) | 539.31 mi (867.93 km) |
| South Lyon to Seagoville (Texas) | 976.63 mi (1,571.74 km) |
| South Lyon to Seal Beach (California) | 1,950.21 mi (3,138.56 km) |
| South Lyon to Searcy (Arkansas) | 661.14 mi (1,064.00 km) |
| South Lyon to Seaside (California) | 2,055.29 mi (3,307.67 km) |
| South Lyon to SeaTac (Washington) | 1,900.47 mi (3,058.51 km) |
| South Lyon to Seattle (Washington) | 1,900.85 mi (3,059.13 km) |
| South Lyon to Sebastian (Florida) | 1,029.73 mi (1,657.19 km) |
| South Lyon to Sebring (Florida) | 1,042.68 mi (1,678.03 km) |
