| South Lyon to Santa Paula (California) | 1,981.45 mi (3,188.84 km) |
| South Lyon to Santa Rosa (California) | 2,053.61 mi (3,304.97 km) |
| South Lyon to Santaquin (Utah) | 1,465.92 mi (2,359.17 km) |
| South Lyon to Santee (California) | 1,925.46 mi (3,098.72 km) |
| South Lyon to Sapulpa (Oklahoma) | 800.25 mi (1,287.88 km) |
| South Lyon to Saraland (Alabama) | 839.10 mi (1,350.40 km) |
| South Lyon to Sarasota (Florida) | 1,046.74 mi (1,684.56 km) |
| South Lyon to Sarasota Springs (Florida) | 1,049.05 mi (1,688.28 km) |
| South Lyon to Saratoga (California) | 2,048.56 mi (3,296.84 km) |
| South Lyon to Saratoga Springs (New York) | 502.37 mi (808.48 km) |
| South Lyon to Saratoga Springs (Utah) | 1,465.18 mi (2,357.98 km) |
| South Lyon to Sartell (Minnesota) | 567.85 mi (913.87 km) |
| South Lyon to Satellite Beach (Florida) | 1,001.55 mi (1,611.85 km) |
| South Lyon to Sauk Rapids (Minnesota) | 564.34 mi (908.21 km) |
| South Lyon to Sault Ste. Marie (Michigan) | 280.03 mi (450.66 km) |
