| South Lyon to Oskaloosa (Iowa) | 469.15 mi (755.03 km) |
| South Lyon to Oswego (Illinois) | 246.17 mi (396.17 km) |
| South Lyon to Oswego (New York) | 367.95 mi (592.17 km) |
| South Lyon to Otsego (Minnesota) | 532.55 mi (857.06 km) |
| South Lyon to Ottawa (Illinois) | 276.73 mi (445.35 km) |
| South Lyon to Ottawa (Kansas) | 664.83 mi (1,069.95 km) |
| South Lyon to Ottumwa (Iowa) | 462.55 mi (744.41 km) |
| South Lyon to Overland (Missouri) | 437.82 mi (704.60 km) |
| South Lyon to Overland Park (Kansas) | 628.13 mi (1,010.88 km) |
| South Lyon to Overlea (Maryland) | 429.42 mi (691.09 km) |
| South Lyon to Oviedo (Florida) | 963.61 mi (1,550.79 km) |
| South Lyon to Owasso (Oklahoma) | 776.63 mi (1,249.87 km) |
| South Lyon to Owatonna (Minnesota) | 494.51 mi (795.83 km) |
| South Lyon to Owensboro (Kentucky) | 372.94 mi (600.19 km) |
| South Lyon to Owings Mills (Maryland) | 415.33 mi (668.41 km) |
