| South Lyon to Olympia (Washington) | 1,930.61 mi (3,107.02 km) |
| South Lyon to Olympia Heights (Florida) | 1,171.62 mi (1,885.54 km) |
| South Lyon to Omaha (Nebraska) | 642.85 mi (1,034.57 km) |
| South Lyon to On Top of the World Designated Place (Florida) | 925.92 mi (1,490.12 km) |
| South Lyon to Onalaska (Wisconsin) | 393.07 mi (632.59 km) |
| South Lyon to Oneida (New York) | 407.35 mi (655.57 km) |
| South Lyon to Oneonta (New York) | 437.48 mi (704.06 km) |
| South Lyon to Ontario (California) | 1,917.42 mi (3,085.79 km) |
| South Lyon to Ontario (Oregon) | 1,669.23 mi (2,686.37 km) |
| South Lyon to Opa-locka (Florida) | 1,160.39 mi (1,867.47 km) |
| South Lyon to Opelika (Alabama) | 683.64 mi (1,100.21 km) |
| South Lyon to Opelousas (Louisiana) | 947.16 mi (1,524.31 km) |
| South Lyon to Orange (California) | 1,935.96 mi (3,115.62 km) |
| South Lyon to Orange (Texas) | 1,019.89 mi (1,641.36 km) |
| South Lyon to Orange City (Florida) | 943.86 mi (1,518.99 km) |
