| South Lyon to Enterprise (Nevada) | 1,736.60 mi (2,794.78 km) |
| South Lyon to Enumclaw (Washington) | 1,887.24 mi (3,037.22 km) |
| South Lyon to Ephrata (Pennsylvania) | 418.30 mi (673.18 km) |
| South Lyon to Erie (Colorado) | 1,120.45 mi (1,803.19 km) |
| South Lyon to Erie (Pennsylvania) | 184.48 mi (296.89 km) |
| South Lyon to Erlanger (Kentucky) | 243.36 mi (391.65 km) |
| South Lyon to Escanaba (Michigan) | 283.91 mi (456.92 km) |
| South Lyon to Escondido (California) | 1,920.31 mi (3,090.44 km) |
| South Lyon to Española (New Mexico) | 1,275.25 mi (2,052.32 km) |
| South Lyon to Essex (Maryland) | 435.00 mi (700.06 km) |
| South Lyon to Essex Junction (Vermont) | 546.22 mi (879.06 km) |
| South Lyon to Estelle (Louisiana) | 942.32 mi (1,516.51 km) |
| South Lyon to Estero (Florida) | 1,112.79 mi (1,790.87 km) |
| South Lyon to Euclid (Ohio) | 124.96 mi (201.11 km) |
| South Lyon to Eufaula (Alabama) | 733.63 mi (1,180.66 km) |
