| South Lyon to Elyria (Ohio) | 109.30 mi (175.90 km) |
| South Lyon to Emeryville (California) | 2,047.54 mi (3,295.20 km) |
| South Lyon to Emmaus (Pennsylvania) | 442.28 mi (711.78 km) |
| South Lyon to Emporia (Kansas) | 715.76 mi (1,151.91 km) |
| South Lyon to Encinitas (California) | 1,932.73 mi (3,110.43 km) |
| South Lyon to Endicott (New York) | 388.62 mi (625.42 km) |
| South Lyon to Endwell (New York) | 390.61 mi (628.62 km) |
| South Lyon to Englewood (Colorado) | 1,125.72 mi (1,811.67 km) |
| South Lyon to Englewood (Florida) | 1,072.74 mi (1,726.41 km) |
| South Lyon to Englewood (New Jersey) | 510.83 mi (822.10 km) |
| South Lyon to Englewood (Ohio) | 182.64 mi (293.93 km) |
| South Lyon to Enid (Oklahoma) | 864.78 mi (1,391.73 km) |
| South Lyon to Ennis (Texas) | 996.92 mi (1,604.39 km) |
| South Lyon to Ensley (Florida) | 848.60 mi (1,365.69 km) |
| South Lyon to Enterprise (Alabama) | 778.69 mi (1,253.18 km) |
