| South Charleston to Southern Pines (North Carolina) | 252.44 mi (406.26 km) |
| South Charleston to Southfield (Michigan) | 296.95 mi (477.89 km) |
| South Charleston to Southgate (Michigan) | 278.15 mi (447.65 km) |
| South Charleston to Southlake (Texas) | 941.61 mi (1,515.37 km) |
| South Charleston to Spanaway (Washington) | 2,126.50 mi (3,422.28 km) |
| South Charleston to Spanish Fork (Utah) | 1,598.78 mi (2,572.98 km) |
| South Charleston to Spanish Lake (Missouri) | 459.65 mi (739.73 km) |
| South Charleston to Spanish Springs (Nevada) | 2,024.75 mi (3,258.52 km) |
| South Charleston to Sparks (Nevada) | 2,028.18 mi (3,264.04 km) |
| South Charleston to Spartanburg (South Carolina) | 235.09 mi (378.35 km) |
| South Charleston to Spearfish (South Dakota) | 1,216.70 mi (1,958.08 km) |
| South Charleston to Speedway (Indiana) | 262.97 mi (423.20 km) |
| South Charleston to Spencer (Iowa) | 776.59 mi (1,249.80 km) |
| South Charleston to Spokane (Washington) | 1,896.41 mi (3,051.97 km) |
| South Charleston to Spokane Valley (Washington) | 1,887.20 mi (3,037.16 km) |
