| South Charleston to Smithville (Missouri) | 694.97 mi (1,118.44 km) |
| South Charleston to Smyrna (Delaware) | 335.20 mi (539.45 km) |
| South Charleston to Smyrna (Georgia) | 346.71 mi (557.97 km) |
| South Charleston to Smyrna (Tennessee) | 311.52 mi (501.34 km) |
| South Charleston to Snellville (Georgia) | 335.24 mi (539.52 km) |
| South Charleston to Snoqualmie (Washington) | 2,100.33 mi (3,380.15 km) |
| South Charleston to Snyder (Texas) | 1,144.69 mi (1,842.20 km) |
| South Charleston to Socastee (South Carolina) | 355.41 mi (571.98 km) |
| South Charleston to Socorro (Texas) | 1,459.30 mi (2,348.52 km) |
| South Charleston to Soddy-Daisy (Tennessee) | 286.41 mi (460.93 km) |
| South Charleston to Solana Beach (California) | 2,016.18 mi (3,244.73 km) |
| South Charleston to Soledad (California) | 2,162.55 mi (3,480.29 km) |
| South Charleston to Solon (Ohio) | 210.82 mi (339.28 km) |
| South Charleston to Somers Point (New Jersey) | 388.40 mi (625.07 km) |
| South Charleston to Somerset (Kentucky) | 180.58 mi (290.62 km) |
