| South Charleston to Siloam Springs (Arkansas) | 719.70 mi (1,158.24 km) |
| South Charleston to Silver Firs (Washington) | 2,115.79 mi (3,405.04 km) |
| South Charleston to Silver Spring (Maryland) | 257.30 mi (414.08 km) |
| South Charleston to Silver Springs Shores (Florida) | 637.96 mi (1,026.70 km) |
| South Charleston to Silverdale (Washington) | 2,139.91 mi (3,443.85 km) |
| South Charleston to Silverton (Oregon) | 2,144.66 mi (3,451.50 km) |
| South Charleston to Simi Valley (California) | 2,067.28 mi (3,326.97 km) |
| South Charleston to Simpsonville (South Carolina) | 251.50 mi (404.75 km) |
| South Charleston to Sioux City (Iowa) | 822.19 mi (1,323.19 km) |
| South Charleston to Sioux Falls (South Dakota) | 860.36 mi (1,384.62 km) |
| South Charleston to Skokie (Illinois) | 407.54 mi (655.87 km) |
| South Charleston to Sleepy Hollow (New York) | 457.90 mi (736.92 km) |
| South Charleston to Slidell (Louisiana) | 721.57 mi (1,161.25 km) |
| South Charleston to Smithfield (North Carolina) | 269.73 mi (434.09 km) |
| South Charleston to Smithfield (Utah) | 1,601.46 mi (2,577.30 km) |
