| South Charleston to Seymour (Indiana) | 229.15 mi (368.79 km) |
| South Charleston to Seymour (Tennessee) | 204.36 mi (328.88 km) |
| South Charleston to Shady Hills (Florida) | 688.34 mi (1,107.78 km) |
| South Charleston to Shafter (California) | 2,066.14 mi (3,325.13 km) |
| South Charleston to Shaker Heights (Ohio) | 216.56 mi (348.53 km) |
| South Charleston to Shakopee (Minnesota) | 751.92 mi (1,210.11 km) |
| South Charleston to Sharon (Pennsylvania) | 209.94 mi (337.86 km) |
| South Charleston to Sharonville (Ohio) | 158.79 mi (255.54 km) |
| South Charleston to Shasta Lake (California) | 2,154.19 mi (3,466.83 km) |
| South Charleston to Shawnee (Kansas) | 707.08 mi (1,137.94 km) |
| South Charleston to Shawnee (Oklahoma) | 866.95 mi (1,395.22 km) |
| South Charleston to Sheboygan (Wisconsin) | 486.93 mi (783.64 km) |
| South Charleston to Shelby (North Carolina) | 211.10 mi (339.73 km) |
| South Charleston to Shelbyville (Indiana) | 233.40 mi (375.62 km) |
| South Charleston to Shelbyville (Kentucky) | 190.81 mi (307.08 km) |
