| South Charleston to Scottsbluff (Nebraska) | 1,181.62 mi (1,901.64 km) |
| South Charleston to Scottsboro (Alabama) | 350.99 mi (564.86 km) |
| South Charleston to Scottsdale (Arizona) | 1,707.50 mi (2,747.96 km) |
| South Charleston to Scranton (Pennsylvania) | 384.16 mi (618.24 km) |
| South Charleston to Seabrook (Maryland) | 266.13 mi (428.29 km) |
| South Charleston to Seabrook (Texas) | 972.17 mi (1,564.56 km) |
| South Charleston to Seaford (New York) | 466.67 mi (751.03 km) |
| South Charleston to Seagoville (Texas) | 920.70 mi (1,481.73 km) |
| South Charleston to Seal Beach (California) | 2,042.21 mi (3,286.61 km) |
| South Charleston to Searcy (Arkansas) | 593.94 mi (955.86 km) |
| South Charleston to Seaside (California) | 2,184.75 mi (3,516.02 km) |
| South Charleston to SeaTac (Washington) | 2,121.42 mi (3,414.10 km) |
| South Charleston to Seattle (Washington) | 2,123.11 mi (3,416.82 km) |
| South Charleston to Sebastian (Florida) | 733.12 mi (1,179.84 km) |
| South Charleston to Sebring (Florida) | 750.89 mi (1,208.45 km) |
