| South Charleston to Enterprise (Nevada) | 1,841.86 mi (2,964.18 km) |
| South Charleston to Enumclaw (Washington) | 2,106.36 mi (3,389.85 km) |
| South Charleston to Ephrata (Pennsylvania) | 322.09 mi (518.35 km) |
| South Charleston to Erie (Colorado) | 1,250.92 mi (2,013.16 km) |
| South Charleston to Erie (Pennsylvania) | 274.76 mi (442.19 km) |
| South Charleston to Erlanger (Kentucky) | 161.59 mi (260.05 km) |
| South Charleston to Escanaba (Michigan) | 580.89 mi (934.85 km) |
| South Charleston to Escondido (California) | 2,002.73 mi (3,223.08 km) |
| South Charleston to Española (New Mexico) | 1,346.49 mi (2,166.96 km) |
| South Charleston to Essex (Maryland) | 291.31 mi (468.82 km) |
| South Charleston to Essex Junction (Vermont) | 615.02 mi (989.78 km) |
| South Charleston to Estelle (Louisiana) | 757.55 mi (1,219.15 km) |
| South Charleston to Estero (Florida) | 823.26 mi (1,324.91 km) |
| South Charleston to Euclid (Ohio) | 224.64 mi (361.52 km) |
| South Charleston to Eufaula (Alabama) | 484.87 mi (780.33 km) |
