| South Bend to Southern Pines (North Carolina) | 581.63 mi (936.04 km) |
| South Bend to Southfield (Michigan) | 163.90 mi (263.78 km) |
| South Bend to Southgate (Michigan) | 161.63 mi (260.11 km) |
| South Bend to Southlake (Texas) | 847.57 mi (1,364.03 km) |
| South Bend to Spanaway (Washington) | 1,807.02 mi (2,908.12 km) |
| South Bend to Spanish Fork (Utah) | 1,324.72 mi (2,131.93 km) |
| South Bend to Spanish Lake (Missouri) | 287.99 mi (463.48 km) |
| South Bend to Spanish Springs (Nevada) | 1,745.00 mi (2,808.31 km) |
| South Bend to Sparks (Nevada) | 1,748.94 mi (2,814.65 km) |
| South Bend to Spartanburg (South Carolina) | 521.22 mi (838.82 km) |
| South Bend to Spearfish (South Dakota) | 904.61 mi (1,455.83 km) |
| South Bend to Speedway (Indiana) | 130.11 mi (209.39 km) |
| South Bend to Spencer (Iowa) | 464.19 mi (747.04 km) |
| South Bend to Spokane (Washington) | 1,574.39 mi (2,533.74 km) |
| South Bend to Spokane Valley (Washington) | 1,565.16 mi (2,518.88 km) |
