| Sioux Falls to Spello | 5,038.96 mi (8,109.43 km) |
| Sioux Falls to Spilamberto | 4,905.51 mi (7,894.66 km) |
| Sioux Falls to Spilimbergo | 4,895.73 mi (7,878.92 km) |
| Sioux Falls to Spinea | 4,900.72 mi (7,886.95 km) |
| Sioux Falls to Spoleto | 5,050.67 mi (8,128.27 km) |
| Sioux Falls to Spoltore | 5,117.83 mi (8,236.35 km) |
| Sioux Falls to Spresiano | 4,890.06 mi (7,869.79 km) |
| Sioux Falls to Squinzano | 5,358.57 mi (8,623.79 km) |
| Sioux Falls to Statte | 5,321.56 mi (8,564.22 km) |
| Sioux Falls to Stezzano | 4,804.29 mi (7,731.75 km) |
| Sioux Falls to Strada | 4,961.37 mi (7,984.55 km) |
| Sioux Falls to Stradella | 4,817.83 mi (7,753.56 km) |
| Sioux Falls to Striano | 5,214.00 mi (8,391.12 km) |
| Sioux Falls to Subiaco | 5,105.68 mi (8,216.79 km) |
| Sioux Falls to Sulmona | 5,130.08 mi (8,256.07 km) |
