| Simi Valley to Siloam Springs (Arkansas) | 1,369.72 mi (2,204.35 km) |
| Simi Valley to Silver Firs (Washington) | 955.78 mi (1,538.17 km) |
| Simi Valley to Silver Spring (Maryland) | 2,316.27 mi (3,727.67 km) |
| Simi Valley to Silver Springs Shores (Florida) | 2,176.91 mi (3,503.40 km) |
| Simi Valley to Silverdale (Washington) | 947.99 mi (1,525.64 km) |
| Simi Valley to Silverton (Oregon) | 771.96 mi (1,242.35 km) |
| Simi Valley to Simpsonville (South Carolina) | 2,066.65 mi (3,325.95 km) |
| Simi Valley to Sioux City (Iowa) | 1,332.42 mi (2,144.32 km) |
| Simi Valley to Sioux Falls (South Dakota) | 1,340.22 mi (2,156.88 km) |
| Simi Valley to Skokie (Illinois) | 1,757.16 mi (2,827.88 km) |
| Simi Valley to Sleepy Hollow (New York) | 2,471.04 mi (3,976.76 km) |
| Simi Valley to Slidell (Louisiana) | 1,708.37 mi (2,749.36 km) |
| Simi Valley to Smithfield (North Carolina) | 2,275.10 mi (3,661.43 km) |
| Simi Valley to Smithfield (Utah) | 643.95 mi (1,036.34 km) |
| Simi Valley to Smithville (Missouri) | 1,378.41 mi (2,218.33 km) |
