| Simi Valley to Scottsbluff (Nebraska) | 972.18 mi (1,564.58 km) |
| Simi Valley to Scottsboro (Alabama) | 1,854.90 mi (2,985.17 km) |
| Simi Valley to Scottsdale (Arizona) | 396.37 mi (637.90 km) |
| Simi Valley to Scranton (Pennsylvania) | 2,376.89 mi (3,825.23 km) |
| Simi Valley to Seabrook (Maryland) | 2,325.53 mi (3,742.57 km) |
| Simi Valley to Seabrook (Texas) | 1,425.08 mi (2,293.44 km) |
| Simi Valley to Seaford (New York) | 2,493.03 mi (4,012.14 km) |
| Simi Valley to Seagoville (Texas) | 1,282.16 mi (2,063.44 km) |
| Simi Valley to Seal Beach (California) | 52.52 mi (84.52 km) |
| Simi Valley to Searcy (Arkansas) | 1,530.27 mi (2,462.73 km) |
| Simi Valley to Seaside (California) | 237.42 mi (382.09 km) |
| Simi Valley to SeaTac (Washington) | 928.95 mi (1,495.01 km) |
| Simi Valley to Seattle (Washington) | 941.13 mi (1,514.60 km) |
| Simi Valley to Sebastian (Florida) | 2,295.81 mi (3,694.75 km) |
| Simi Valley to Sebring (Florida) | 2,247.98 mi (3,617.78 km) |
