| Shepherdsville to Southern Pines (North Carolina) | 398.81 mi (641.83 km) |
| Shepherdsville to Southfield (Michigan) | 336.16 mi (541.00 km) |
| Shepherdsville to Southgate (Michigan) | 320.18 mi (515.29 km) |
| Shepherdsville to Southlake (Texas) | 731.17 mi (1,176.70 km) |
| Shepherdsville to Spanaway (Washington) | 1,951.98 mi (3,141.41 km) |
| Shepherdsville to Spanish Fork (Utah) | 1,394.72 mi (2,244.58 km) |
| Shepherdsville to Spanish Lake (Missouri) | 250.36 mi (402.91 km) |
| Shepherdsville to Spanish Springs (Nevada) | 1,821.38 mi (2,931.23 km) |
| Shepherdsville to Sparks (Nevada) | 1,824.59 mi (2,936.39 km) |
| Shepherdsville to Spartanburg (South Carolina) | 296.68 mi (477.46 km) |
| Shepherdsville to Spearfish (South Dakota) | 1,040.10 mi (1,673.87 km) |
| Shepherdsville to Speedway (Indiana) | 128.64 mi (207.02 km) |
| Shepherdsville to Spencer (Iowa) | 610.56 mi (982.60 km) |
| Shepherdsville to Spokane (Washington) | 1,726.50 mi (2,778.53 km) |
| Shepherdsville to Spokane Valley (Washington) | 1,717.38 mi (2,763.86 km) |
