| Shepherdsville to Scottsbluff (Nebraska) | 986.76 mi (1,588.04 km) |
| Shepherdsville to Scottsboro (Alabama) | 231.41 mi (372.42 km) |
| Shepherdsville to Scottsdale (Arizona) | 1,490.13 mi (2,398.13 km) |
| Shepherdsville to Scranton (Pennsylvania) | 583.16 mi (938.50 km) |
| Shepherdsville to Seabrook (Maryland) | 483.45 mi (778.04 km) |
| Shepherdsville to Seabrook (Texas) | 789.05 mi (1,269.86 km) |
| Shepherdsville to Seaford (New York) | 677.76 mi (1,090.75 km) |
| Shepherdsville to Seagoville (Texas) | 712.96 mi (1,147.39 km) |
| Shepherdsville to Seal Beach (California) | 1,826.47 mi (2,939.43 km) |
| Shepherdsville to Searcy (Arkansas) | 384.37 mi (618.58 km) |
| Shepherdsville to Seaside (California) | 1,974.88 mi (3,178.26 km) |
| Shepherdsville to SeaTac (Washington) | 1,948.54 mi (3,135.87 km) |
| Shepherdsville to Seattle (Washington) | 1,951.06 mi (3,139.92 km) |
| Shepherdsville to Sebastian (Florida) | 766.63 mi (1,233.77 km) |
| Shepherdsville to Sebring (Florida) | 766.37 mi (1,233.35 km) |
