| Shepherdsville to Enterprise (Nevada) | 1,628.28 mi (2,620.46 km) |
| Shepherdsville to Enumclaw (Washington) | 1,932.40 mi (3,109.90 km) |
| Shepherdsville to Ephrata (Pennsylvania) | 532.40 mi (856.81 km) |
| Shepherdsville to Erie (Colorado) | 1,045.86 mi (1,683.15 km) |
| Shepherdsville to Erie (Pennsylvania) | 412.41 mi (663.70 km) |
| Shepherdsville to Erlanger (Kentucky) | 93.23 mi (150.03 km) |
| Shepherdsville to Escanaba (Michigan) | 541.32 mi (871.17 km) |
| Shepherdsville to Escondido (California) | 1,786.11 mi (2,874.47 km) |
| Shepherdsville to Española (New Mexico) | 1,129.99 mi (1,818.54 km) |
| Shepherdsville to Essex (Maryland) | 507.53 mi (816.79 km) |
| Shepherdsville to Essex Junction (Vermont) | 792.26 mi (1,275.01 km) |
| Shepherdsville to Estelle (Louisiana) | 616.02 mi (991.39 km) |
| Shepherdsville to Estero (Florida) | 830.06 mi (1,335.85 km) |
| Shepherdsville to Euclid (Ohio) | 333.80 mi (537.19 km) |
| Shepherdsville to Eufaula (Alabama) | 420.63 mi (676.93 km) |
