| Shafter to Southern Pines (North Carolina) | 2,227.69 mi (3,585.13 km) |
| Shafter to Southfield (Michigan) | 1,974.18 mi (3,177.14 km) |
| Shafter to Southgate (Michigan) | 1,976.40 mi (3,180.70 km) |
| Shafter to Southlake (Texas) | 1,269.19 mi (2,042.56 km) |
| Shafter to Spanaway (Washington) | 819.81 mi (1,319.35 km) |
| Shafter to Spanish Fork (Utah) | 521.94 mi (839.99 km) |
| Shafter to Spanish Lake (Missouri) | 1,606.50 mi (2,585.40 km) |
| Shafter to Spanish Springs (Nevada) | 289.77 mi (466.33 km) |
| Shafter to Sparks (Nevada) | 284.28 mi (457.51 km) |
| Shafter to Spartanburg (South Carolina) | 2,091.92 mi (3,366.61 km) |
| Shafter to Spearfish (South Dakota) | 1,022.36 mi (1,645.32 km) |
| Shafter to Speedway (Indiana) | 1,817.01 mi (2,924.20 km) |
| Shafter to Spencer (Iowa) | 1,384.19 mi (2,227.64 km) |
| Shafter to Spokane (Washington) | 846.97 mi (1,363.07 km) |
| Shafter to Spokane Valley (Washington) | 847.82 mi (1,364.43 km) |
