| Shafter to Enterprise (Nevada) | 225.80 mi (363.38 km) |
| Shafter to Enumclaw (Washington) | 822.61 mi (1,323.86 km) |
| Shafter to Ephrata (Pennsylvania) | 2,346.98 mi (3,777.09 km) |
| Shafter to Erie (Colorado) | 834.06 mi (1,342.30 km) |
| Shafter to Erie (Pennsylvania) | 2,136.77 mi (3,438.81 km) |
| Shafter to Erlanger (Kentucky) | 1,907.89 mi (3,070.45 km) |
| Shafter to Escanaba (Michigan) | 1,812.10 mi (2,916.30 km) |
| Shafter to Escondido (California) | 202.49 mi (325.87 km) |
| Shafter to Española (New Mexico) | 736.82 mi (1,185.79 km) |
| Shafter to Essex (Maryland) | 2,340.12 mi (3,766.06 km) |
| Shafter to Essex Junction (Vermont) | 2,483.13 mi (3,996.21 km) |
| Shafter to Estelle (Louisiana) | 1,730.07 mi (2,784.29 km) |
| Shafter to Estero (Florida) | 2,287.99 mi (3,682.16 km) |
| Shafter to Euclid (Ohio) | 2,062.86 mi (3,319.85 km) |
| Shafter to Eufaula (Alabama) | 1,963.17 mi (3,159.42 km) |
