| Sesto San Giovanni to Southern Pines (North Carolina) | 4,481.02 mi (7,211.51 km) |
| Sesto San Giovanni to Southfield (Michigan) | 4,328.61 mi (6,966.22 km) |
| Sesto San Giovanni to Southgate (Michigan) | 4,337.98 mi (6,981.31 km) |
| Sesto San Giovanni to Southlake (Texas) | 5,330.48 mi (8,578.59 km) |
| Sesto San Giovanni to Spanaway (Washington) | 5,397.76 mi (8,686.86 km) |
| Sesto San Giovanni to Spanish Fork (Utah) | 5,482.33 mi (8,822.96 km) |
| Sesto San Giovanni to Spanish Lake (Missouri) | 4,771.10 mi (7,678.34 km) |
| Sesto San Giovanni to Spanish Springs (Nevada) | 5,755.08 mi (9,261.91 km) |
| Sesto San Giovanni to Sparks (Nevada) | 5,761.25 mi (9,271.84 km) |
| Sesto San Giovanni to Spartanburg (South Carolina) | 4,601.56 mi (7,405.50 km) |
| Sesto San Giovanni to Spearfish (South Dakota) | 4,993.56 mi (8,036.36 km) |
| Sesto San Giovanni to Speedway (Indiana) | 4,566.18 mi (7,348.56 km) |
| Sesto San Giovanni to Spencer (Iowa) | 4,756.00 mi (7,654.05 km) |
| Sesto San Giovanni to Spokane (Washington) | 5,234.99 mi (8,424.90 km) |
| Sesto San Giovanni to Spokane Valley (Washington) | 5,229.88 mi (8,416.68 km) |
