| Sesto San Giovanni to Shotley Bridge | 808.44 mi (1,301.06 km) |
| Sesto San Giovanni to Shrewsbury | 732.83 mi (1,179.37 km) |
| Sesto San Giovanni to Sidcup | 582.86 mi (938.02 km) |
| Sesto San Giovanni to Sidmouth | 675.13 mi (1,086.51 km) |
| Sesto San Giovanni to Sileby | 681.20 mi (1,096.28 km) |
| Sesto San Giovanni to Sittingbourne | 558.36 mi (898.59 km) |
| Sesto San Giovanni to Skegness | 659.78 mi (1,061.82 km) |
| Sesto San Giovanni to Skelmersdale | 770.50 mi (1,240.00 km) |
| Sesto San Giovanni to Skipton | 767.20 mi (1,234.69 km) |
| Sesto San Giovanni to Sleaford | 673.37 mi (1,083.68 km) |
| Sesto San Giovanni to Slough | 609.34 mi (980.63 km) |
| Sesto San Giovanni to Small Heath | 692.73 mi (1,114.84 km) |
| Sesto San Giovanni to Smethwick | 697.78 mi (1,122.97 km) |
| Sesto San Giovanni to Snaresbrook | 592.99 mi (954.33 km) |
| Sesto San Giovanni to Snodland | 567.21 mi (912.83 km) |
