| Seal Beach to Southern Pines (North Carolina) | 2,190.81 mi (3,525.77 km) |
| Seal Beach to Southfield (Michigan) | 1,970.19 mi (3,170.72 km) |
| Seal Beach to Southgate (Michigan) | 1,971.05 mi (3,172.10 km) |
| Seal Beach to Southlake (Texas) | 1,206.61 mi (1,941.85 km) |
| Seal Beach to Spanaway (Washington) | 949.55 mi (1,528.15 km) |
| Seal Beach to Spanish Fork (Utah) | 564.45 mi (908.40 km) |
| Seal Beach to Spanish Lake (Missouri) | 1,584.06 mi (2,549.29 km) |
| Seal Beach to Spanish Springs (Nevada) | 417.30 mi (671.59 km) |
| Seal Beach to Sparks (Nevada) | 412.26 mi (663.47 km) |
| Seal Beach to Spartanburg (South Carolina) | 2,052.33 mi (3,302.91 km) |
| Seal Beach to Spearfish (South Dakota) | 1,062.04 mi (1,709.19 km) |
| Seal Beach to Speedway (Indiana) | 1,799.81 mi (2,896.51 km) |
| Seal Beach to Spencer (Iowa) | 1,393.21 mi (2,242.15 km) |
| Seal Beach to Spokane (Washington) | 961.86 mi (1,547.96 km) |
| Seal Beach to Spokane Valley (Washington) | 961.96 mi (1,548.13 km) |
