| Seal Beach to Enterprise (Nevada) | 224.14 mi (360.72 km) |
| Seal Beach to Enumclaw (Washington) | 951.36 mi (1,531.06 km) |
| Seal Beach to Ephrata (Pennsylvania) | 2,332.61 mi (3,753.97 km) |
| Seal Beach to Erie (Colorado) | 839.59 mi (1,351.19 km) |
| Seal Beach to Erie (Pennsylvania) | 2,130.56 mi (3,428.80 km) |
| Seal Beach to Erlanger (Kentucky) | 1,886.65 mi (3,036.27 km) |
| Seal Beach to Escanaba (Michigan) | 1,826.85 mi (2,940.03 km) |
| Seal Beach to Escondido (California) | 71.76 mi (115.48 km) |
| Seal Beach to Española (New Mexico) | 697.37 mi (1,122.31 km) |
| Seal Beach to Essex (Maryland) | 2,321.99 mi (3,736.88 km) |
| Seal Beach to Essex Junction (Vermont) | 2,486.88 mi (4,002.24 km) |
| Seal Beach to Estelle (Louisiana) | 1,659.26 mi (2,670.32 km) |
| Seal Beach to Estero (Florida) | 2,214.91 mi (3,564.55 km) |
| Seal Beach to Euclid (Ohio) | 2,054.29 mi (3,306.06 km) |
| Seal Beach to Eufaula (Alabama) | 1,907.44 mi (3,069.73 km) |
