| Scottsbluff to Southern Pines (North Carolina) | 1,384.23 mi (2,227.71 km) |
| Scottsbluff to Southfield (Michigan) | 1,043.00 mi (1,678.55 km) |
| Scottsbluff to Southgate (Michigan) | 1,047.47 mi (1,685.74 km) |
| Scottsbluff to Southlake (Texas) | 711.52 mi (1,145.07 km) |
| Scottsbluff to Spanaway (Washington) | 989.87 mi (1,593.04 km) |
| Scottsbluff to Spanish Fork (Utah) | 433.31 mi (697.35 km) |
| Scottsbluff to Spanish Lake (Missouri) | 739.01 mi (1,189.32 km) |
| Scottsbluff to Spanish Springs (Nevada) | 850.24 mi (1,368.33 km) |
| Scottsbluff to Sparks (Nevada) | 854.19 mi (1,374.69 km) |
| Scottsbluff to Spartanburg (South Carolina) | 1,265.94 mi (2,037.34 km) |
| Scottsbluff to Spearfish (South Dakota) | 181.36 mi (291.88 km) |
| Scottsbluff to Speedway (Indiana) | 919.93 mi (1,480.48 km) |
| Scottsbluff to Spencer (Iowa) | 442.06 mi (711.43 km) |
| Scottsbluff to Spokane (Washington) | 783.74 mi (1,261.31 km) |
| Scottsbluff to Spokane Valley (Washington) | 775.30 mi (1,247.72 km) |
