| Santa Maria de Cayon to Southern Pines (North Carolina) | 3,942.71 mi (6,345.18 km) |
| Santa Maria de Cayon to Southfield (Michigan) | 3,856.43 mi (6,206.32 km) |
| Santa Maria de Cayon to Southgate (Michigan) | 3,863.46 mi (6,217.64 km) |
| Santa Maria de Cayon to Southlake (Texas) | 4,853.36 mi (7,810.73 km) |
| Santa Maria de Cayon to Spanaway (Washington) | 5,154.23 mi (8,294.93 km) |
| Santa Maria de Cayon to Spanish Fork (Utah) | 5,128.17 mi (8,252.99 km) |
| Santa Maria de Cayon to Spanish Lake (Missouri) | 4,300.34 mi (6,920.73 km) |
| Santa Maria de Cayon to Spanish Springs (Nevada) | 5,446.26 mi (8,764.91 km) |
| Santa Maria de Cayon to Sparks (Nevada) | 5,452.20 mi (8,774.47 km) |
| Santa Maria de Cayon to Spartanburg (South Carolina) | 4,071.25 mi (6,552.05 km) |
| Santa Maria de Cayon to Spearfish (South Dakota) | 4,628.46 mi (7,448.79 km) |
| Santa Maria de Cayon to Speedway (Indiana) | 4,085.83 mi (6,575.50 km) |
| Santa Maria de Cayon to Spencer (Iowa) | 4,339.24 mi (6,983.34 km) |
| Santa Maria de Cayon to Spokane (Washington) | 4,966.17 mi (7,992.28 km) |
| Santa Maria de Cayon to Spokane Valley (Washington) | 4,959.91 mi (7,982.20 km) |
