| Santa Maria to Enterprise (Nevada) | 302.69 mi (487.13 km) |
| Santa Maria to Enumclaw (Washington) | 851.44 mi (1,370.27 km) |
| Santa Maria to Ephrata (Pennsylvania) | 2,426.04 mi (3,904.34 km) |
| Santa Maria to Erie (Colorado) | 913.65 mi (1,470.38 km) |
| Santa Maria to Erie (Pennsylvania) | 2,216.24 mi (3,566.69 km) |
| Santa Maria to Erlanger (Kentucky) | 1,986.30 mi (3,196.63 km) |
| Santa Maria to Escanaba (Michigan) | 1,891.42 mi (3,043.95 km) |
| Santa Maria to Escondido (California) | 229.53 mi (369.39 km) |
| Santa Maria to Española (New Mexico) | 811.51 mi (1,306.00 km) |
| Santa Maria to Essex (Maryland) | 2,418.90 mi (3,892.84 km) |
| Santa Maria to Essex Junction (Vermont) | 2,562.73 mi (4,124.31 km) |
| Santa Maria to Estelle (Louisiana) | 1,797.61 mi (2,892.97 km) |
| Santa Maria to Estero (Florida) | 2,354.94 mi (3,789.92 km) |
| Santa Maria to Euclid (Ohio) | 2,142.22 mi (3,447.58 km) |
| Santa Maria to Eufaula (Alabama) | 2,035.44 mi (3,275.72 km) |
