| Santa Margarita to Southern Pines (North Carolina) | 4,369.92 mi (7,032.71 km) |
| Santa Margarita to Southfield (Michigan) | 4,293.21 mi (6,909.26 km) |
| Santa Margarita to Southgate (Michigan) | 4,300.11 mi (6,920.35 km) |
| Santa Margarita to Southlake (Texas) | 5,289.17 mi (8,512.10 km) |
| Santa Margarita to Spanaway (Washington) | 5,567.81 mi (8,960.52 km) |
| Santa Margarita to Spanish Fork (Utah) | 5,561.12 mi (8,949.76 km) |
| Santa Margarita to Spanish Lake (Missouri) | 4,736.97 mi (7,623.42 km) |
| Santa Margarita to Spanish Springs (Nevada) | 5,873.34 mi (9,452.22 km) |
| Santa Margarita to Sparks (Nevada) | 5,879.32 mi (9,461.86 km) |
| Santa Margarita to Spartanburg (South Carolina) | 4,500.10 mi (7,242.21 km) |
| Santa Margarita to Spearfish (South Dakota) | 5,062.08 mi (8,146.64 km) |
| Santa Margarita to Speedway (Indiana) | 4,521.91 mi (7,277.31 km) |
| Santa Margarita to Spencer (Iowa) | 4,776.42 mi (7,686.90 km) |
| Santa Margarita to Spokane (Washington) | 5,384.92 mi (8,666.19 km) |
| Santa Margarita to Spokane Valley (Washington) | 5,378.88 mi (8,656.48 km) |
